本研究针对早产儿常见慢性肺病支气管肺发育不良（BPD）的发病机制，通过非靶向代谢组学发现色氨酸代谢通路异常激活，重点探究了代谢产物5-羟色胺（5-HT）通过转谷氨酰胺酶2（TGM2）介导的蛋白血清素化修饰，破坏肺泡上皮细胞功能并导致肺泡发育障碍的新 ...

Shanghai Institutes for Biological Sciences and Shanghaitech University have identified dopamine D2 receptor and/or 5-HT receptor agonists reported to be useful for the treatment of depression and ...