An investigation by researchers from Case Western Reserve University School of Medicine in the US has filled in a missing link between the toxic build-up of proteins in the neurodegenerative condition ...

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by the aggregation of alpha-synuclein in the brain. Now, scientists have developed a radioligand that facilitates the ...

In the healthy brain, α-synuclein leads a dynamic life near the synapse, where it frequently shifts its conformation as well as its association with membrane vesicles. Disruption of this active ...

The study, conducted in mice and published in the Nature journal, identifies a key role of gut macrophages -- a specialised immune cell that kills pathogens -- in the transfer of toxic proteins from ...

Proteins form the building blocks of life, but when they form unusual clumps inside the brain, they raise an alarm that something isn't right.

A new study has developed an assay that can identify incorrectly folded α-synuclein, a biomarker of synucleinopathies, in patient serum. Synucleinopathies are neurodegenerative diseases, such as ...

Much of the research into α-synuclein, the major component of Lewy bodies in Parkinson’s and other neurodegenerative diseases, focuses on its role in synaptic vesicles and membranes. But could other ...

After three years of study, the researchers found that alpha-synuclein, a protein closely linked to Parkinson’s disease, ...

A small new trial published in the journal Nature Medicine describes what would be two firsts for Parkinson's disease, if they pan out: a diagnostic test and a potential immune-based treatment that ...

Parkinson’s disease has long been defined by the slow, relentless loss of dopamine-producing neurons, with treatments focused ...