Researchers used a novel phosphate-activation reagent, 2-MeImIm-Cl, in an improved coupling reaction to increase the yield of ADP- or ATP-containing molecules. Unlike traditional reactions, the ...

In a recent study posted to the bioRxiv* preprint server, researchers discovered compounds able to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain 1 (Mac1) and ...

Poly (adenosine diphosphate [ADP]–ribose) polymerase (PARP) inhibitors have efficacy as single agents in the treatment of recurrent ovarian cancer and as maintenance therapy after patients have had a ...