Apoptosis, a form of regulated cell death, reflects a cell's decision to die in response to cues and is executed by intrinsic cellular machinery. Unregulated cell death (often called necrosis ...

helped us understand the mechanisms by which these genes control apoptosis. The structure of CD95 suggested that it belonged to the tumour necrosis factor (TNF) receptor family and that there ...

They began searching for evidence that Ance cells were producing markers of necrosis and autophagy, the other, less-common forms of cell death. But they failed to find evidence that any of the three ...

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues are not clear.

Combining an existing small-molecule protein therapy called tumor necrosis factor related apoptosis-inducing ligand (TRAIL) with focused ultrasound (FUS) can significantly reduce tumor size and ...

Researchers identified a Mtb effector protein, mammalian cell entry 3C (Mce3C), which promotes host cell necroptosis while inhibiting apoptosis. Mechanistically, Mtb Mce3C can bind host cathepsin ...