三级淋巴结构（TLS）通过高效呈递肿瘤抗原并迅速激活效应免疫细胞来增强抗肿瘤免疫。近期的研究阐明了 TLS 所驱动的抗肿瘤免疫反应及其在癌症免疫治疗中的关键预后价值。这些发现促使我们利用肿瘤突变负荷的免疫原性作用来探索下一代癌症免疫疗法。然而，许多实体瘤缺乏可检测到的肿瘤浸润淋巴细胞区，尤其是在对免疫治疗无响应的癌症中。

A newly identified mechanism lends credence to the idea that MS may be treatable by targeting EBV-infected B-cells, a study found.

Initial results as promising as those in lupus and other non-cancer diseases driven by B c ...