The discovery of Hoogsteen base pairs, an alternative pairing mode to the canonical Watson–Crick structure, has significantly broadened our understanding of DNA dynamics. This conformation, in which ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...

In a step toward treating mitochondrial diseases, researchers at the University Medical Center Utrecht and their colleagues have used mitochondrial base editing (mtBE) to successfully edit harmful ...

Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality in ...

But the act of constructing DNA sequences to realize those designs has been a significant bottleneck. Due to technological limitations, chemical DNA synthesis has been limited only to creating short ...

Armed with base editors, scientists from the laboratory of David Liu, PhD, professor and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute, and their ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

The goal of gene therapy is to permanently cure hereditary diseases. One of the most promising technologies for this is the CRISPR/Cas system, colloquially known as gene scissors. These can cut and ...

Here’s what you’ll learn when you read this story: We are generating staggering amounts of data every day. Data centers just can’t keep up with the demand. With data storage needs expected to soar in ...