Tropane alkaloids (TAs) are heterocyclic nitrogenous metabolites found across seven orders of angiosperms, including Malpighiales (Erythroxylaceae) and Solanales (Solanaceae). Despite the ...

Researchers report the first successful microbial biosynthesis of the tropane alkaloids hyoscyamine and scopolamine, a class of neuromuscular blockers naturally found in plants in the nightshade ...

Plant Physiology, Vol. 174, No. 1 (May 2017), pp. 47-55 (16 pages) Pyrrolizidine alkaloids (PAs) are toxic secondary metabolites that are found in several distantly related families of the angiosperms ...

Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by combining transcriptome and ...

The elucidation of the biosynthetic pathway of ipecacuanha alkaloids shows how two distantly related plant species could develop the same substance independently Plants produce an enormous abundance ...

Making chemical handles that latch onto amino acids is a strategy used to make covalent drugs, antibody-drug conjugates, and biochemical probes. Cysteine and lysine are common points of attachment, ...

Complex polycylic structures are found in nearly every biosynthetic class of natural products. In particular, an amazing range of rigid densely functionalized polycylic compounds are formed from ...

Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to ...

Researchers at Johannes Gutenberg University Mainz (JGU) have mastered a nearly 50-year-old challenge of electrosynthetic chemistry, namely the electrochemical synthesis of thebaine. The chemists had ...

Tropane alkaloids are a particular class of plant derived compounds that have been exploited by mankind since the domestication of medicinal plants. The distribution of these alkaloids is scattered ...