Osteocytes, the most abundant cells in bone tissue, have long been underestimated in their functional capacity. Traditionally viewed as passive entities, recent research has illuminated their pivotal ...

Endothelial-to-Osteoblast Conversion (EC-to-OSB) regulates bone formation and homeostasis via the Kindlin-2/Piezo1/TGFβ/Runx2 axis. Reduced Kindlin-2 in endothelial ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. This ...

Scientists develop a new material that protects stem cells and helps repair facial bone damage by reducing harmful stress and inflammation in the body. (Nanowerk Spotlight) Maxillofacial bone defects ...

Bone marrow plays a crucial role in maintaining hematopoietic stem cells and bone homeostasis. However, research has been hindered by a lack of effective markers and monoclonal antibodies to ...

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes ...