In mammalian cells, DNA double-strand breaks (DSBs) are repaired predominantly by the non-homologous end joining (NHEJ) pathway, which includes subpathways that can repair different DNA-end ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...

DNA damage has been associated with aging and disease. Double-strand breaks are one of the worst forms of damage. New research shines a light on the repair process.

Repair of broken chromosomes and triggering of the DNA damage response Broken chromosomes must be repaired if a cell is to survive; consequently cells have evolved a variety of mechanisms to repair ...

BERKELEY, CA — Ionizing radiation, toxic chemicals, and other agents continually damage the body's DNA, threatening life and health: unrepaired DNA can lead to mutations, which in turn can lead ...

DNA damage plays a role in the pathogenesis of heart failure. On a bright sunny day, it’s second nature to protect our skin from ultraviolet damage with sunscreen. By applying this protective spray, ...

The findings, presented by Dr. Enrique Gonzalez-Duran and Prof. Dr. Ralph Bock from the Max Planck Institute of Molecular Plant Physiology in Nature Plants ("Suppression of plastid-to-nucleus gene ...

RNA actively participates in repairing double-strand DNA breaks by binding to broken DNA ends, aligning sequences, and influencing repair outcomes.

More often, the strand of DNA is permanently broken, which could potentially lead to additional genetic abnormalities in the embryo." Dr Nada Kubikova, University of Oxford.

High-resolution cryo-electron microscopy has revealed the structural mechanism by which human RAD51 mediates strand exchange during homologous recombination, a key DNA repair pathway.