Bufadienolides, a class of cardiotonic steroids primarily isolated from toad venom, have emerged as potent agents in the field of cancer therapeutics. Their bioactivity is largely attributed to their ...

Capsaicin, the bioactive compound responsible for the characteristic spiciness of chilli peppers, has attracted considerable attention for its anticancer properties. In various cancer cell types, ...

The field of regulated cell death has undergone a transformative shift with the discovery of novel modalities beyond apoptosis, such as ferroptosis, which ...

ETX-19477 is a potent, selective inhibitor of poly (ADP-ribose) glycohydrolase (PARG), an enzyme that plays a role in the DNA damage response. 3,4 Upon PARG inhibition, the agent is intended to ...

Hoth Therapeutics, Inc. (NASDAQ: HOTH), a clinical-stage biopharmaceutical company focused on developing innovative therapeutics, today announced that the China National Intellectual Property ...

Cells in our body are programmed to die after a certain period of time—a natural process known as apoptosis or “cell suicide.” This process is essential for maintaining the body’s balance. When aged ...

Albizzia julibrissin is a widely distributed plant in China. Its dried stem bark has been used in traditional oriental medicine to treat insomnia, diuresis, sthenia, ascaricide, and confusion.

From the deep sea to the shallow seafloor, researchers are uncovering unusual sugars that do something extraordinary to cancer cells: they push them toward self-destruction instead of survival. Rather ...

Combination therapies represent a promising frontier in cancer treatment, addressing the critical need to enhance efficacy while minimizing resistance. By combining different therapeutic agents and ...

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...