高氧暴露显著提升BPD小鼠肺组织中Caspase-8表达和酶活性，其水平与肺损伤程度正相关。 抑制Caspase-8减轻NLRP3炎症小体激活 Casp8i处理使NLRP3、ASC（凋亡相关斑点样蛋白）表达降低，同时抑制焦亡执行蛋白GSDMD的剪切活化，效果优于单独使用caspase-1抑制剂。

本研究针对抗有丝分裂药物诱导的卵巢癌细胞命运不明确问题，揭示了cGAS/TBK1介导的IRF3磷酸化通过招募RIPK1/FADD/caspase-8复合体 ...

Kashkar团队在细胞培养物和小鼠中研究了caspase-8的生物学作用。他们发现caspase-8的酶活性是抑制细胞焦亡所必需的。Kashkar解释说，“我们发现酶活性 ...

Caspase-8 is frequently deficient in several kinds of human tumors, suggesting that certain effects of this enzyme restrict tumor development. To examine the nature of the cellular function whose ...

The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively ...

The study 'Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis' was published in Nature. The research team studied the biological roles of caspase-8 in cell cultures and mice.

DUBLIN--(BUSINESS WIRE)--The "Caspase 8 - Pipeline Review, H2 2018" drug pipelines has been added to ResearchAndMarkets.com's offering.Caspase 8 (Apoptotic Cysteine Protease or Apoptotic Protease ...

Caspase-8 mutations cause autoimmunity. Studies of human immunodeficiency patients link caspase-8 to homeostatic regulation of the immune system. Jonathan Weitzman. Jonathan Weitzman. This person does ...

AnaSpec has introduced its SensoLyte™ Homogeneous AFC Caspase-8 Assay Kit. The SensoLyte™ Homogeneous AFC Caspase-8 Assay Kit uses Ac-IETD-AFC as the fluorogenic indicator to measure caspase-8 ...