The central dogma of molecular biology describes the flow of genetic information. It was first described by Francis Crick in 1956 as one-way traffic: as: "DNA makes RNA and RNA makes protein." A ...

The central dogma of molecular biology is key to understanding the relationship between genotype and phenotype, although it remains a challenging concept to teach and learn. We describe an activity ...

As cellular machines and processes that regulate the flow of genomic information have come into sharper focus, a new level of chemical control has become possible. The scope of such chemical ...

For decades, RNA was seen as a simple slave to DNA. Newer research shows it has an active and critical role in every disease from Alzheimer's to cancer. One of the great revolutions in modern science ...

Small molecules have critical roles at all levels of biological complexity and yet remain orphans of the central dogma. Chemical biologists, working with small molecules, expand our understanding of ...