In cats, the fur pigmentation gene is X-linked, and depending on which copy of the X chromosome each cell chooses to leave active, either an orange or black coat color results. X inactivation only ...

In each female cell, one X chromosome must be inactivated—crumpled up in such a way that the genetic code it contains cannot be read out. RNA plays an important role in this inactivation process.

The silencing of the one X chromosome in XX cells is mediated by XIST, a long noncoding RNA that is randomly transcribed from only one X early in development. It coats the DNA and shuts down gene ...

Inactivation also explained why XO female mice were able to survive with a single X chromosome. In her second paper on this subject (1962), Lyon extended her analysis to other species, including ...

During early female development, one of the two X chromosomes is transcriptionally silenced through X inactivation. This ensures that females produce a similar number of X chromosome gene products to ...

The X contains more genes related to brain function than does any other chromosome. “The X chromosome may be a treasure trove ...

UCSF researchers found that brain cells age more quickly when they rely solely on the X chromosome inherited from a female's ...

But in every cell of their body, just one X chromosome is needed—so the other is randomly inactivated. Some cells use only a maternal X chromosome; others rely only on the paternal X.

The scientists explained that this difference was due to a higher level of OGT in mutant females in some tissues, due to an escape mechanism from X chromosome inactivation (XCI). XCI occurs in ...

A UCSF study reveals that maternal X chromosome expression may accelerate brain aging and cognitive decline. Female mice with ...