Extrachromosomal circular DNA (ecDNA) represents a distinct genomic entity that exists independent of the primary chromosomal structure. In cancer, ecDNA is recognised as a potent driver of oncogene ...

Scientists have discovered a way to target elusive circular fragments of DNA that drive the survival of some of the most aggressive cancers, paving the way for future treatments. In three ...

Circular single-stranded DNA viruses represent a diverse group of pathogens that possess a covalently closed, circular single-stranded DNA genome. Their small genomes belie a sophisticated replication ...

Pancreatic cancer is one of the deadliest cancers worldwide, with a five-year survival rate of 13%. The poor prognosis is due in part both to late detection and the cancer’s capacity to adapt and ...

Figure 1. Design and synthesis of circAMO . (a) Synthesis of a single-molecule ring by rigid regulation of selectivity; (b) Schematic diagram of circAMO design; (c) Synthesis of circAMO; (d) ...

Immunofluorescence images showing that cells with higher levels of the cancer-promoting MYC protein (red) also tend to exhibit high levels of DNA damage (green), suggesting that too much MYC leads to ...