Circular single-stranded DNA viruses represent a diverse group of pathogens that possess a covalently closed, circular single-stranded DNA genome. Their small genomes belie a sophisticated replication ...

Extrachromosomal circular DNA (ecDNA) represents a distinct genomic entity that exists independent of the primary chromosomal structure. In cancer, ecDNA is recognised as a potent driver of oncogene ...

Scientists have discovered a way to target elusive circular fragments of DNA that drive the survival of some of the most aggressive cancers, paving the way for future treatments. In three ...

Figure 1. Design and synthesis of circAMO . (a) Synthesis of a single-molecule ring by rigid regulation of selectivity; (b) Schematic diagram of circAMO design; (c) Synthesis of circAMO; (d) ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...