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基于扩散模型的单细胞转录组扰动预测去偏框架:dbDiffusion的创新与应用
本文介绍了一种名为dbDiffusion的创新计算框架,该框架结合扩散模型(Diffusion Model)与分类器无关引导(classifier-free guidance),通过变分自编码器(VAE)在潜在空间生成单细胞转录组数据,能够准确预测未见过的遗传扰动(如CRISPR扰动)对基因表达的影响。
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