In this article the problem of obtaining the maximum likelihood estimates of the parameters from a special type of linear combination of discrete probability functions is discussed. It is shown that ...

Consider the regression model Y = h(x)+ε, where h is an unknown smooth regression function and ε is a random error with unknown distribution. To estimate the ...

We describe a protocol for the discovery of synergistic drug combinations for the treatment of disease. Synergistic drug combinations lead to the use of drugs at lower doses, which reduces side ...