The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

SEATTLE, Jan. 23, 2025 /PRNewswire/ -- Arzeda, the industry-leading Protein Design Company™, today announced it has been selected for an award from the Defense Advanced Research Projects Agency (DARPA ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

One of those Baker lab spin-offs is Vilya, which uses computational protein design to create membrane- permeable macrocyclic drugs. When the biotech venture capital firm Arch Venture Partners met the ...

Using the MProt-DPO framework, scientists created synthetic versions of malate dehydrogenase that preserve the protein’s critical structure and key binding areas. Harnessing the power of artificial ...

Harnessing AI and exascale supercomputing, a research team led by the U.S. Department of Energy’s Argonne National Laboratory has developed a computing framework to speed up the design of new proteins ...

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...

The 2024 Nobel Prize in Chemistry recognized Dr. David Baker for his pioneering work in computational protein design, along with Drs. Demis Hassabis and John Jumper for their contributions to protein ...

From growth hormones to cancer drugs, small molecules play a crucial role in our health. Monitoring them is essential to keeping us healthy; it enables physicians to calculate dosages and patients to ...