Model predicts effect of mutations on sequences up to 1 million base pairs in length and is adept at tackling complex ...

The tool helps scientists understand how single-letter mutations and distant DNA regions influence gene activity, shaping ...

The brains at Google DeepMind in London have developed a new artificial intelligence (AI) tool that can accurately predict ...

Scientists from Oxford's Radcliffe Department of Medicine have achieved the most detailed view yet of how DNA folds and functions inside living cells, revealing the physical structures that control ...

The discovery of Hoogsteen base pairs, an alternative pairing mode to the canonical Watson–Crick structure, has significantly broadened our understanding of DNA dynamics. This conformation, in which ...

Nucleotides are the building blocks of the two nucleic acids, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). As such, they are also the building blocks of you and every other lifeform on ...

A new LUMC study has changed our understanding of how cells work. Researchers have discovered that the CFAP20 protein acts as ...

In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

In a step toward treating mitochondrial diseases, researchers at the University Medical Center Utrecht and their colleagues have used mitochondrial base editing (mtBE) to successfully edit harmful ...

While researchers have long appreciated the enormous potential of genome editing to treat disease, applications of these technologies in humans have historically been limited by safety concerns. Even ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...