本研究系统揭示了DNA双链断裂修复后的一个被长期忽视的层面：染色质结构与基因功能的不可逆改变。这种结构性与功能性损伤可稳定地传递给子代细胞，形成一种可遗传的基因表达缺陷，被作者定义为“染色质疲劳（chromatin fatigue）”。染色质疲劳为理解细胞老化、癌症发生、环境应激应答及基因编辑潜在副作用提供了新的理论框架，也提示未来在研究DNA修复及基因治疗时，必须同时关注三维染色质层面的长期影响 ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

An international research team has identified a human protein, ANKLE1, as the first DNA-cutting enzyme (nuclease) in mammals ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...

To our immune system, a potentially lifesaving gene therapy can look a lot like a dangerous infection. That's because most ...

New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in ...

A Targeted Methylation–Based Multicancer Early Detection Blood Test Preferentially Detects High-Grade Prostate Cancer While Minimizing Overdiagnosis of Indolent Disease Enzymatic conversion–mediated ...

Learn more about what how humans ended up having Neanderthal DNA in their genome and what it means if you have it.

The fern Tmesipteris oblanceolata, which scientists just discovered has the longest known genome of any organism. Ferns are known among scientists for having particularly large genomes. Pol Fernandez ...

The vampire squid is a creature straight out of a gothic horror film. It lurks in the deep-sea abyss, cloaked in dark, webbed ...