针对濒危淡水贻贝因隐蔽生活史和低丰度导致的监测难题，美国环保署等机构开发了针对北方步枪壳 (Epioblasma rangiana)、鼻烟盒 (Epioblasma triquetra)和溪浮贻 (Alasmidonta varicosa)的qPCR eDNA检测技术。研究通过74种非靶标物种验证了特异性，野外样本检测准确率达100%，结合 occupancy modeling 实现>95%检出率 ...

AlphaGenome scores mutation effects across coding and non-coding DNA, bringing gene insights to the base-pair level.

Moving toward clinical development, the researchers demonstrated efficient delivery of mRNA mitochondrial base editors using ...

Modeling DNA methyltransferase function to predict epigenetic correlation patterns in healthy and cancer cells. Journal: Proceedings of the National Academy of Sciences of the United States of America ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations ...

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

These cells came from a person with Gitelman-like syndrome, a disorder linked to mitochondrial dysfunction. The correction ...

Almost all cervical cancers are caused by human papillomaviruses (HPVs). In most cases, HPV DNA is integrated into the human genome. We found that tumor-specific, HPV-human DNA junctions are ...

Long-term, persistent weekly or more frequent cannabis smoking leaves a distinct and partially reversible epigenetic ...

Before Watson and Crick basked in Nobel glory, before The Double Helix mythologized their genius, there was the photo. Photo 51 — crisp, clear, and groundbreaking — captured by Dr. Rosalind Franklin, ...