Without a connecting link, the CMG complex could just "run off" and leave pol-a/primase behind. This would create long regions of vulnerable ssDNA. Therefore, the second rule in DNA replication is ...

cellular concentrations of replication origins and pre-replication complex proteins, human diseases associated with defects in DNA replication and repair, and a list of therapeutic drugs that ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells ...

DNA is a complex molecule that consists of two strands coiled around each other to form ... This process is essential for the proper functioning and survival of all living organisms. DNA replication ...

Conjugation is a form of horizontal gene transfer that allows the exchange of genetic material between two organisms or cells ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous ... These include the ATM and ...

DNA replication, repair, and damage response, collectively called the 3Rs, support genome stability and faithful genetic inheritance. Proteins involved in the 3Rs are genome guardians that prevent a ...

Nucleic acids are complex biological molecules that store and transmit genetic information ... genetic information from one generation to the next is fundamental to the continuity of life. During cell ...

While some drugs can block the virus' DNA replication and alleviate symptoms ... as possible are needed to fully understand this complex, three-dimensional (3D) assembly process.

Transposons, also known as jumping genes or mobile genetic elements, can replicate and reintegrate themselves into the genome, posing a threat to genomic integrity by inducing DNA rearrangements and ...