DNA damage that causes replication forks to stall can be bypassed via translesion synthesis (TLS). New work has identified a bifunctional human primase and TLS polymerase, PrimPol, that ...

When these pathways are activated, DNA replication is suppressed at sites in the genome called origins; at the same time, the progression of DNA replication forks also slows down. Replication forks, ...

“DNA damage response pathways cause replication forks to slow down progression by about ten-fold. This ten-fold slowdown means that synthesis of the cell’s genome, which usually takes about 12 hours, ...

DNA replication and repair are critical processes that ensure the correct genetic material of a biological system is carried on. DNA continually undergoes a process of replication and division and ...

Forks colliding: How DNA breaks during re-replication Date: June 4, 2015 Source: Whitehead Institute for Biomedical Research Summary: Leveraging a novel system designed to examine the double ...

Despite the importance of DNA replication, numerous aspects of this process are still poorly understood. One fundamental question is: how do replication forks efficiently progress through chromatin?

CAMBRIDGE, Mass. (June 4, 2015) - Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

The parental DNA (blue) opens up to allow the replication of two new strands (red). The BIR repair process leads to the aberrant duplication of DNA fragments (green).

DNA 'replication fork' reconstituted for the first time Date: July 9, 2014 Source: Rockefeller University Summary: While scientists have had an idea of the molecular tools that cells use to ...

DNA Replication: Within the nucleus of every cell are long strings of DNA, the code that holds all the information needed to make and control every cell within a living organism.