So why would normal cells need ATR? There are other circumstances that cause replication to go awry. One is that the DNA template somehow becomes defective during replication, and causes the ...

According to the conservative replication model, the entire original DNA double helix serves as a template for a new double helix, such that each round of cell division produces one daughter cell ...

the idea that replication forks would form at origins of DNA replication and proceed without impairment to copy the chromosomes has proven naive. It is now clear that replication forks stall ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous ... after a successful search ...

During DNA replication, the double helix unwinds, and each strand serves as a template for synthesizing a new complementary strand. Adenine on the template strand will always pair with thymine on the ...

Each strand serves two primary purposes: acting as a template during DNA replication and providing instructions for protein synthesis in a process called transcription. Replication and ...

The DNA molecule has a double-helix structure. To be copied, the two strands of the helix are first separated and each one ...