Decades of research has viewed DNA as a sequence-based instruction manual; yet every cell in the body shares the same genes – so where is the language that writes the memory of cell identities?

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

A stretch of viral DNA in the mouse genome gives cells in early-stage embryos the potential to become almost any cell type in ...

A 14,400-year-old wolf puppy’s last meal is shedding light on the last days of one of the Ice Age’s most iconic megafauna ...

“We’re only just beginning to understand the full majesty of life on Earth,” wrote the founding members of the Earth BioGenome Project in 2018. The ambitious project raised eyebrows when first ...

研究这个蛋白很有趣，因为它控制着细菌中大量基因的表达，当病毒或其他微生物将外源DNA插入结核菌基因组时，这些“外来户”可能扰乱细菌的正常运作。因此，细菌必须识别并抑制这些基因的表达。传统观点认为，蛋白质通过结合到DNA的特定序列上，像锁和钥匙一样精确配对，从而阻止细胞机器“读取”DNA；但Lsr2采用了完全不同的策略。研究人员发现，Lsr2会结合到富含腺嘌呤（A）和胸腺嘧啶（T）的大片DNA区域。

While tools like CRISPR have blown the field of genome hacking wide open, being able to predict what will happen when you tinker with the code underlying the living things on our planet is still ...

If you liked this story, share it with other people. Tyler Kartzinel likens protecting biodiversity to enhancing cellphone networks. His analogy is pretty straightforward: look for gaps in coverage, ...