How is all of that DNA packaged so tightly into chromosomes and squeezed into ... may be highly irregular and not quite the uniform structure depicted in instructive drawings such as Figure ...

The nucleus of each human body cell contains 46 chromosomes. Each chromosome contains about 1000 genes. There is enough DNA in all the cells in a human body to stretch to the sun and back again ...

Rethinking Models of DNA Organization in Micrometer‐Sized Chromosomes from the Perspective of the Nanoproperties of Chromatin Favoring a Multilayer Structure, Small Structures (2024).

MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a ...

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

Scientists suggest understanding ecDNA’s role in pancreatic cancer could potentially guide future strategies for making ...

elegans are hermaphrodites capable of self-fertilization, typically producing hermaphroditic offspring with two X chromosomes. Males, with their single X chromosome ... the researchers used nuclear ...

Pancreatic cancer’s deadly resilience may be tied to extrachromosomal DNA, which allows tumor cells to rapidly adapt to ...

Two new studies show how a seeming tangle of DNA is actually organized into a structure that coordinates thousands of genes ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

Kossel isolated cytosine from calf thymus tissues and found that it was a component of nucleic acids. This discovery, along with the identification of other nitrogenous bases, laid the foundation for ...