We identify drug metabolites from liver microsomes (e.g., mouse, rat, dog, and human) and in vivo studies. Identifying the unstable moieties can help guide the synthetic optimization of lead compounds ...

Most drugs are metabolized by CYP3A enzymes, and variations in expression levels of these enzymes are believed to determine whether patients will have a positive or adverse drug response.

Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological ... as they discuss the current understanding of the mechanisms that contribute to DILI and how ...

we assay stability in liver microsomes and perform reaction phenotyping against an array of CYP450s. Core personnel provide advice on the use of the supported methods for a wide variety of ...

Scientists at Michigan Medicine have made a significant breakthrough in treating nonalcoholic fatty liver disease (NAFLD), a ...

By Sriparna Roy (Reuters) -Akero Therapeutics shares gained 106% before the bell on Monday, after its lead drug showed it can ...

"Fortunately, we're not aware of similar chlorcyclizine metabolism differences ... by preventing liver damage at a much earlier stage. The antihistamine allergy drugs have been used safely for ...

One such disease, nonalcoholic steatohepatitis (NASH), is characterized by dysregulated metabolism ... relevant reductions in markers of liver fat, inflammation and fibrosis (Fig.

Obesity is a significant global health challenge, linked to an increased risk of conditions like diabetes, heart disease, and fatty liver. Despite its widespread impact, there is currently no ...