本研究揭示了核膜KASH蛋白UNC-83通过可变剪接产生的不同亚型（UNC-83a/b与UNC-83c）差异调控kinesin-1（驱动蛋白-1）活性的新机制 ...

Regulation of organelle transport by molecular motors along the cytoskeletal microtubules is central to maintaining cellular functions. Here, we show that the ubiquitous tau-related ...

Cytoplasmic dynein is a homodimenc AAA+ motor that transports a multitude of cargos toward the microtubule minus end. How the two catalytic head domains interact and move relative to each other during ...

The Derr lab pursues the biophysical, biochemical, and cell biological mechanisms of the cytoskeletal molecular motors dynein and kinesin. The group studies these molecular machines in two ways: 1) at ...