Estrogen agonists/antagonists, also referred to as selective estrogen-receptor (ER) modulators (SERMs), are one group of compounds that are being used or evaluated for both osteoporosis prevention ...

Their study, published recently in Nature, focuses on what is known as the estrogen receptor, a protein linked in previous research to the development of roughly 70% of all breast tumors.

Raloxifene can be classified as a second-generation SERM. A SERM interacts with estrogen receptors, functioning as an estrogen agonist in some tissues and an antagonist in other tissues.

The researchers found that imlunestrant prolonged progression-free survival (PFS) when compared to standard care in patients with ESR1 mutations, but there was no PFS benefit observed in the overall ...

Newly discovered estrogen receptor-dependent signaling pathways demonstrate that estrogen functions in the cytosol as well as in the nucleus. The classic estrogen receptor signaling pathway occurs ...

If the trial is successful, the firm's complete estrogen receptor antagonist would complement its other biomarker-driven breast cancer assets.

Discover the role of phytoestrogens, including soy, in menopause management and breast cancer prevention. Learn how these ...

Olema is dedicated to transforming breast cancer treatment through its pipeline of innovative therapies, including its lead product candidate, palazestrant, an oral estrogen receptor antagonist ...