Selective estrogen-receptor (ER) modulators (SERMs) are synthetic nonsteroidal compounds that switch on and switch off target sites throughout the body. Tamoxifen, the pioneering SERM, blocks estrogen ...

Estrogen is commonly referred to as a sex hormone due to its key role in the development of secondary sex characteristics and the regulation of the female ...

We review key topics in the management of estrogen receptor (ER)–positive human epidermal growth factor receptor 2–negative breast cancer. The single biggest challenge in management of this disease is ...

A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with ...