Repression-associated ER-binding sites exhibit differential recruitment of nuclear receptor coregulators. (a) Recruitment of nuclear receptor coregulators was determined by sequential ChIP steps ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. AstraZeneca. (2020, January 30). Targeting the Estrogen Receptor in Breast Cancer.

Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer. JCO 41 , 1331-1338 (2023). DOI: 10.1200 ...

At a molecular, structural level, those drugs interact with the pocket where estrogen binds and use a single, carefully positioned side chain to block the receptor's growth promoting activity.

Mutations in the androgen-receptor gene have been shown to cause androgen resistance in 46,XY humans 1,2 and in murine models, 3 but estrogen-receptor mutations are rare. The action of estrogen in ...

When estrogen binds to receptor sites in cancer cells, it makes them grow. Tamoxifen works by sitting on the estrogen receptors in breast tissue. This prevents estrogen from binding to the cancer ...

Because estrogen receptor binders can prevent cancer-causing compounds from binding to estrogen, they may be able to thwart the growth of cancerous tumors. Koffas says that they were able to achieve ...

Tamoxifen, on the other hand, competes for estrogen receptor binding, so "a modest elevation of the very low serum estrogen levels" with hormone therapy "is not assumed to counteract the receptor ...

Methods: ERα ChIP-seq data from proliferating MCF-7 breast cancer cells was used from a publically available dataset [Ross-Innes, 2010]. The transcription start sites of the 58 genes in the gene set ...

An estrogen receptor that promotes cancer also causes drug resistance. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 09 / 210923122418.htm ...

"We have shown that a couple of compounds are good estrogen receptor binders in vitro, meaning they could inhibit estrogen from binding to its receptor," says Koffas, "so if further testing in ...