Repression-associated ER-binding sites exhibit differential recruitment of nuclear receptor coregulators. (a) Recruitment of nuclear receptor coregulators was determined by sequential ChIP steps ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. AstraZeneca. (2020, January 30). Targeting the Estrogen Receptor in Breast Cancer.

Methods: ERα ChIP-seq data from proliferating MCF-7 breast cancer cells was used from a publically available dataset [Ross-Innes, 2010]. The transcription start sites of the 58 genes in the gene set ...

e15647Background: Antiestrogens are a mainstay of treatment for estrogen receptor positive (ER+) breast cancer in both the adjuvant and the advanced/metastatic settings. ... (RAD1901), a novel ...

Discover how high-speed AFM reveals estrogen receptor binding to DNA, enhancing understanding of gene regulation. ... Lim K, et al. Zooming into gene activation: estrogen receptor α dimerization and ...

"We have shown that a couple of compounds are good estrogen receptor binders in vitro, meaning they could inhibit estrogen from binding to its receptor," says Koffas, "so if further testing in ...

Because estrogen receptor binders can prevent cancer-causing compounds from binding to estrogen, they may be able to thwart the growth of cancerous tumors. Koffas says that they were able to achieve ...

When estrogen binds to receptor sites in cancer cells, it makes them grow. Tamoxifen works by sitting on the estrogen receptors in breast tissue. This prevents estrogen from binding to the cancer ...

At a molecular, structural level, those drugs interact with the pocket where estrogen binds and use a single, carefully positioned side chain to block the receptor's growth promoting activity.

An estrogen receptor that promotes cancer also causes drug resistance. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 09 / 210923122418.htm ...

Mutations in the androgen-receptor gene have been shown to cause androgen resistance in 46,XY humans 1,2 and in murine models, 3 but estrogen-receptor mutations are rare. The action of estrogen in ...