An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.

Please use one of the following formats to cite this article in your essay, paper or report: APA. AstraZeneca. (2020, January 30). Targeting the Estrogen Receptor in Breast Cancer.

In this section, we review key current topics in the management of estrogen receptor–positive breast cancer. We review therapeutic options that may reduce the risk of late relapse, how to optimally ...

(Funded by Pfizer and Arvinas Estrogen Receptor; VERITAC-2 ClinicalTrials.gov number, NCT05654623.) Notes. This article was published on May 31, 2025, at NEJM.org.

An estrogen receptor that promotes cancer also causes drug resistance. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 09 / 210923122418.htm ...

New generation estrogen receptor-targeted agents in breast cancer: present situation and future prospectives. Acta Materia Medica. 2024. Vol. 3(1):57-71. DOI: 10.15212/AMM-2024-0006. DOI.

To study the function of this new variant, they stably transduced and overexpressed ERα36 in human embryonic kidney cells (HEK293), which do not express the receptor. 2 They showed that ERα36 lacks ...

HER2 tumor marker tests are used to determine whether breast cancer is HER2 positive or negative. A person is a candidate for ...

Estrogen's role in canine mammary cancer is more complex than previously understood, according to new research. The nuanced findings may help explain why dogs spayed at a young age are more likely ...

Researchers at Huntsman Cancer Institute identified potential new treatment options for people with endometrial cancer.Endometrial cancer is the most common gynecological cancer and high levels of ...