NRIF3 is an estrogen-inducible nuclear receptor coregulator that stimulates estrogen receptor-α (ERα) transactivation functions and associates with the endogenous ER and its target gene promoter ...

Phase I and Pharmacokinetic Study of a New Taxoid, RPR 109881A, Given as a 1-Hour Intravenous Infusion in Patients With Advanced Solid Tumors ABSTRACT: The sex hormone estrogen is important for many ...

However, these drugs also have many estrogenic effects depending on the tissue and gene, and they are more appropriately called selective estrogen receptor modulators (SERMs). SERMs bind ER, alter ...

Similarly, estrogen elevates skin's levels of hyaluronic acid, improving barrier function, protecting cells against oxidative ...

Mutations in the androgen-receptor gene have been shown to cause androgen resistance in 46,XY humans 1,2 and in murine models, 3 but estrogen-receptor mutations are rare. The action of estrogen in ...

Drugs that disrupt the bridge could affect how the two portions are able to work together, inhibiting receptor function. Said Yang, “Disruption of the bridge prevents the two major parts of the ...

Study in Cancer Research used mice with one copy of p53 silenced and estrogen-receptor gene expression doubled. genprowebdirectory Sign in. Welcome! Log into your account. your username. your ...

An estrogen receptor that promotes cancer also causes drug resistance. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 09 / 210923122418.htm ...

with slides / Estrogen-only hormone therapy showed a trend toward increasing dementia and was associated with a greater decline in cognitive function compared with placebo, according to new data ...

(Funded by Pfizer and Arvinas Estrogen Receptor; VERITAC-2 ClinicalTrials.gov number, NCT05654623.) Notes. This article was published on May 31, 2025, at NEJM.org.

Menopause and estrogen affect muscle function Date: October 2, 2017 Source: University of Jyväskylä Summary: Estrogen acts as a regulator of muscle energy metabolism and muscle cell viability ...