Extrachromosomal circular DNA (ecDNA) represents a distinct genomic entity that exists independent of the primary chromosomal structure. In cancer, ecDNA is recognised as a potent driver of oncogene ...

Now, researchers from UC San Diego and their colleagues have found that HPV DNA hybridizes with human DNA genes in oropharyngeal cancer cells, forming extrachromosomal circular DNA (ecDNA) that ...

Neuroblastoma can be a particularly insidious cancer. In about half of all cases, tumors regress, even without therapy. In the other half, tumors grow very quickly. These tumors often respond well to ...

Scientists have discovered a way to target elusive circular fragments of DNA that drive the survival of some of the most aggressive cancers, paving the way for future treatments. In three ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...