A defect in a key cell-signaling pathway has been discovered that researchers say contributes to both overproduction of toxic protein in the brains of Alzheimer’s disease patients as well as ...

An activated microglial cell in the brain of cGAS/STING activated mice. [Gulen et al. Nature 02 August 2023. DOI: 10.1038/s41586-023-06373-1] Low-grade inflammation contributes to age-related ...

TGF-β and HIPPO Signaling Pathways. The TGF-β pathway is essential for regulating cell growth, differentiation, and immune responses.

Recent studies provide new insights into signaling by mutant KRAS, inhibitors of which have provided modest benefits for patients. Skip to main content The New England Journal of Medicine NEJM ...