G protein-coupled receptor kinase 2 (GRK2) has emerged as a pivotal regulator in the pathophysiology of heart failure. GRK2 mediates the phosphorylation of activated G protein‐coupled receptors (GPCRs ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

Structure and the tethered activation mechanism of aGPCRs. (A) The basic structure of aGPCRs. This article highlights the critical role of mechanosensitive aGPCRs in human health and disease, setting ...

In this international study, the scientists showed that one of the adhesion G protein-coupled receptors – GPR133 – is activated by the androgenic steroid hormone 5α-DHT. Created in BioRender.