How is it that your body with all of its specialized organs developed from a single cell? Scientists are exploring how gene expression patterns and their timing regulate cell differentiation. Today, ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...

Multiple Independent Molecular Signals Converge to Validate GRI-0621 as a Potential Disease-Modifying TherapyLA JOLLA, CA, (GLOBE ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. This is the first detailed study ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

Metabolic diseases such as obesity, fatty liver, and insulin resistance are rapidly increasing worldwide, but fundamental ...

Single-cell analyses revealed molecular profiles that can distinguish PTSD from depression, potentially leading to better drugs for this psychiatric disorder. To test this hypothesis, Girgenti and his ...

A research team has developed a way to produce a subset of highly specialised brain neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury, laying foundations ...