引言：不及时治疗，风险有多大？艾滋病病毒（HIV）本身并不直接致命，但它会持续攻击人体免疫系统的核心——CD4+T淋巴细胞。若不进行任何干预，经过数年至十多年的潜伏期，免疫系统将逐渐崩溃，进入艾滋病期。此时，机体将失去抵御各种感染和肿瘤的能力，一些对 ...

At the cellular level, HIV-1 transmission involves a highly coordinated process whereby the virus binds to CD4 receptors and one of two coreceptors—CCR5 (R5) or CXCR4 (X4)—on host immune cells, ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Previous experience with antiretroviral compounds has indicated that viral replication can be affected through the use of agents that target multiple steps in the HIV lifecycle. Even within the ...