Researchers created a human liver tissue model that reproduces early metabolic dysfunction-associated steatotic liver disease ...

A human model of immune-driven liver injury Some drugs that pass early safety testing can still cause idiosyncratic drug-induced liver injury (iDILI)—a rare immune reaction that can lead to severe ...

Assessing the toxicity of food contaminants—including carcinogenic potential—is a major challenge in evaluating the risks ...

Researchers successfully implanted a genetically modified pig liver into a human, proving that such an organ can function for an extended period. The graft supported essential liver processes before ...

Doctors in China have become the first to report details about a transplant of a genetically modified pig liver into a human. The liver was transplanted last year into a person who was brain-dead, and ...

Using human induced pluripotent stem cells, researchers have built a miniature 3D liver model that replicates the critical interaction between hepatocytes and stellate cells. As chronic liver disease ...

Together, they form a fully human, immune-competent model that mirrors the genetic and immune diversity of real patients. As a proof-of-concept, the research team recreated liver injury triggered by ...

In a human organoid-based mechanistic investigation, researchers revealed how an immunosuppressive drug, antithymocyte ...

Human periportal assembloid, showcasing the three key cell types of the liver: portal fibroblasts (magenta), cholangiocytes (green), and hepatocyte nuclei (blue). All cell borders are delineated in ...