Checkpoint inhibitors that block PD1 and CTLA4 signalling get all of the credit for setting off the immuno-oncology tsunami. But the cytokine IL-2 put these waves in motion decades before. In 1984, a ...

A pleiotropic cytokine central to the regulation of T-cell responses, interleukin 2 (IL-2), plays an essential role in a huge range of other immune modulatory actions. Image Credit: Sino Biological ...

Interleukin-2 (IL-2) is a cytokine, a type of immune system signaling molecule, that plays a crucial role in the body's response to microbial infections and in distinguishing between self and non-self ...

Werewolf Therapeutics is developing a "conditionally activated" interleukin-2 (IL-2) drug for the treatment of stage IV melanoma and metastatic cancers. The drug aims to deliver therapeutic doses of ...

A new study shows how two subsets of one type of immune cell -- the CD8 T cell -- develop to provide either short-term or long-term immune protection. The study focuses on one factor that guides that ...