The nanocapsules have an unprecedented drug-to-lipid ratio and an in vitro cytotoxicity up to 1000-fold higher than the free drug. Analysis of the mechanism of nanocapsule formation suggests that ...

As noted above, the three proposed models are based on data for human oral clearance, rat LD50, and in-vitro cytotoxicity. Oral clearance is a measure of the rate of drug removal from the body ...

Through a series of in vitro experiments, including cytotoxicity assays, cell proliferation tests, and anchorage-independent cell growth assays, it was demonstrated that dronedarone had a ...