As noted above, the three proposed models are based on data for human oral clearance, rat LD50, and in-vitro cytotoxicity. Oral clearance is a measure of the rate of drug removal from the body ...

The nanocapsules have an unprecedented drug-to-lipid ratio and an in vitro cytotoxicity up to 1000-fold higher than the free drug. Analysis of the mechanism of nanocapsule formation suggests that ...

Through a series of in vitro experiments, including cytotoxicity assays, cell proliferation tests, and anchorage-independent cell growth assays, it was demonstrated that dronedarone had a ...