研究结论和讨论部分指出，IVDD 由多种因素引发，当前治疗手段无法阻止其进展。本研究首次证实 Piezo1 参与 IVDD，它通过增加软骨细胞 ROS 生成、提高氧化应激水平、促进 ECM 降解、引发炎症反应和诱导细胞凋亡等方式，推动椎间盘退变。Yap 在 Piezo1 下游发挥作用，介导其信号转导。抑制 Yap 可改善 CEP 退变。这一研究为 IVDD ...

Extracellular vesicles (EVs) have constituted a prominent area of research in recent years. As a mediator of intercellular communication, EVs play an ...

A pioneering study has revealed that increased stiffness in the extracellular matrix (ECM) of spinal discs impairs energy production in nucleus pulposus cells (NPCs), a key factor in intervertebral ...

Our research focuses on regenerative approaches for the musculoskeletal system - primarily the intervertebral disc - as well as skin and lung tissues. We utilize a range of tools, including cells, ...

Lower back pain can have multiple causes, and its treatment depends on the specific source of discomfort. Here are 5 reasons experts give for lower back pain.