Lipid metabolism and storage mechanisms underpin essential cellular processes, ensuring energy homeostasis and membrane integrity. At the cellular level, lipids are synthesised and stored ...

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC). This ...

Metabolic dysregulation has been implicated in major depressive disorder (MDD), but the causal relationship between plasma metabolites and MDD remains unclear. Although previous studies have suggested ...

MD Anderson studies reveal how cancer cells rewire metabolism to spread. A glucose–fructose mix promotes colorectal metastasis via cholesterol pathways, while fatty-acid oxidation driven by ACBP ...

Disrupted lipid metabolism in the central nervous system triggers α-Syn aggregation, ferroptosis, mitochondrial dysfunction, and neuroinflammation. All of these contribute to the onset and progression ...

近日，河南医药大学的研究团队在国际顶级期刊Nature Communications上发表了一项重要研究，题为“METTL3 abrogation promotes glioma progression through regulating the ISG15-FASN axis-mediated lipid metabolism in ...

Mutations in the lipid transporter ABCA7 are known to elevate the risk of Alzheimer’s disease, but how they do so has been murky. Now, scientists led by Li-Huei Tsai at MIT in Cambridge, Massachusetts ...

In Alzheimer’s disease, microglia pack on fat, which impairs phagocytosis. Now, scientists led by Christiane Ruedl of Nanyang Technological University, Singapore, report that blocking lipid buildup in ...

Researchers have discovered a new way in which the liver regulates its consumption of sugar and fat. This could potentially increase the effectiveness of weight-loss and diabetes medication. Many ...