Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.

Fats are an important part of the human diet as a major source of energy. Around 90% of the fat stores are on top of muscle, so just under the skin. However, excessive dietary fat intake leads to fat ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

Mitochondrial respiratory complexes (Complexes I–V) and their assembly into respiratory supercomplexes (SCs) are fundamental to liver bioenergetics, redox homeostasis, and metabolic adaptability.

Some high-dose detox “natural” supplements, such as green tea extract, can lead to liver inflammation, reflected in elevated ...

If you are generally healthy, your body does not need a reset as the liver works best with time and consistency, meaning fewer repeated stresses and enough recovery time to heal and function properly ...

The liver, located in the upper right side of the abdomen, is the body’s largest organ and one of the most important. The liver performs hundreds of vital functions, including converting nutrients ...

Chronic liver disease gets worse when the liver's immune system stays overactive, resulting in ongoing inflammation and scarring. Signals from the gut make the situation worse by encouraging immune ...