直接MALDI-TOF MS快速鉴定病原体在血液等无菌体液中的应用研究，发现其可在30-60分钟内完成病原体鉴定，但存在革兰氏阴性菌识别率高于阳性菌及真菌的现象，主要受样本中微生物浓度、细胞壁结构及蛋白质提取效率影响，同时面临低灵敏度样本、基质干扰、多 ...

艰难梭菌（Clostridioides difficile）感染（CDI）是最常见的医疗相关感染之一，导致显著的发病率和死亡率。CDI的诊断需要临床评估和实验室检测。本研究旨在评估MALDI-TOF质谱技术在识别产毒艰难梭菌菌株方面的有效性。 方法 从2019年5月到2024年3月，所有通过PCR检测 ...

Background. Early identification of pathogens from blood cultures using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry may optimize the choice of empirical ...

Conventional methods of identifying a positive blood culture require waiting for the blood culture broth to grow the organism and once positive, it has to be subcultured to specific media such as ...

Identification and confirmation of microbial isolates is crucial in the analysis workflow, providing decision-makers the information required to release or hold products. Despite the difficulties in ...

MBT Sepsityper Kit US IVD enables rapid, specific detection of many cases of bacteremia-induced sepsis to assist infectious disease specialists in potentially life-saving decisions Used for MALDI ...

In a recent study published in BMC Microbiology, researchers developed the Novel Organism Verification and Analysis (NOVA) algorithm to systematically analyze bacterial isolates unidentified using ...

Until recently, clinical diagnostic laboratories predominantly relied on conventional phenotypic ways of diagnosing infections, and sometimes on gene sequencing techniques. The latest advancements in ...

What is time-of-flight mass spectrometry? How ToF MS has gained more interest since the commercialization of MALDI. Why a high-speed ADC is key to ToF MS performance. Mixed-signal front end that ...