An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Scientists have discovered how LINE-1, a “jumping gene” that makes up 17% of the human genome, inserts itself into DNA. Using ...

They observe how the mobile DNA LINE-1 copies its sequence in human cells, revealing the precise mechanism of the ORF2p gene.

Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human ...

Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and replication ...

These burrowing animals have a biological mechanism that does the opposite of what it does in humans: it repairs DNA instead ...

Most of the cells in our body carry the genome, and those cells are constantly bombarded with environmental influences including UV rays, pollution, alcohol, and other exposures that can damage the ...