A research group has demonstrated that overexpression of Cdc10-dependent transcript 1 (CDT1), a key regulator of DNA ...

The research also shows that upon differentiation, mouse ES cells adopt replication characteristics similar to those of non-pluripotent cells. Furthermore, some features of DNA replication observed in ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and replication ...

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and ...

"Use it or lose it" goes the adage, applied liberally to everything from our muscles to our minds, especially as we age. Yet when it comes to the brain, such usage is not entirely a good thing: While ...

Researchers have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. The new approach offers a clearer window than ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 39 (September 27, 2022), pp. 1-3 (3 pages) A substantial number of human cancers are telomerase-negative ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...