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Micro-C-ChIP技术解密组蛋白修饰特异的精细染色质三维结构
本研究针对传统Hi-C技术测序深度要求高、难以大规模应用的瓶颈,开发了Micro-C-ChIP这一新型染色质构象捕获技术。通过将Micro-C的高分辨率与染色质免疫沉淀(ChIP)的特异性结合,研究人员在小鼠胚胎干细胞(mESC)和人类视网膜色素上皮细胞(hTERT-RPE1)中成功 ...
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